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Cancer 122 , 155164 (2008)

Relative risks for men and women in the 1950 study were taken as the odds ratios indicated by the published frequency distributions of the age matched cases and controls.7 Relative risks from the studies were then combined with national lung cancer mortality rates from 1950 and 1990 respectively to estimate the absolute hazards in various categories of smoker, former smoker, and non-smoker

Rather than measuring B12 directly, the MR used 8 genetic variants (SNPs) known to raise B12 levels as a proxy for lifelong B12 levels