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This means that the ratio of mortality among smokers to that among persons who have never smoked is much more extreme now (Figure 1, and the 50-year trends shown in the Supplementary Appendix, available with the full text of this article at NEJM.org) than it was half a century earlier, when the epidemic of smoking-attributable deaths was at an earlier stage

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CDC, Behavioral Risk Factor Surveillance System, 2022