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So, what exactly is the difference between synthetic nicotine and tobacco-derived nicotine
It was the first authoritative source-of-disease KOS that was a nosological grouping rather than a classification (Robb-Smith 1969)

Green Tobacco Sickness occurs when workers absorb nicotine through their skin while having prolonged contact with tobacco plants.[57] Researchers have documented dizziness, headaches, nausea, and vomiting as the most common symptoms of acute nicotine poisoning.[58] In some cases, these symptoms may be linked to or exacerbated by pesticide exposure or working in conditions of high heat and high humidity without sufficient rest, shade, and hydration.[59] Acute nicotine poisoning generally lasts between a few hours and a few days,[60] and although it is rarely life-threatening, severe cases may result in dehydration which requires emergency treatment.[61] Children are particularly vulnerable to nicotine poisoning because of their size, and because they are less likely than adults to have developed a tolerance to nicotine.[62] The long-term effects of nicotine absorption through the skin have not been studied,[63] although the long-term effects of consuming tobacco products containing nicotine has been well documented

A 2020 Centers for Disease Control and Prevention youth survey found that 20% of high school and 10% of middle school students reported current e-cigarette use
Its slightly sweet and earthy profile hits all the right notes, while its versatility means you can use it as a filler, enhancer, or enjoy it as is