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In addition, ROS induce matrix degeneration through the upregulation of matrix-degrading enzyme expression while this effect is abolished by antioxidant treatment 123,125

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Morning (30 minutes before breakfast): Lactobacillus reuteri, 10 billion CFU 16 ounces of water With breakfast: Bifidobacterium lactis, 5 billion CFU (increase to 10 billion in week two if tolerated) One serving of fermented food (yogurt, kefir, or sauerkraut) Evening (with dinner): Bifidobacterium longum, 5 billion CFU 3 to 5 grams prebiotic fiber (PHGG or acacia) If experiencing diarrhea, add: Saccharomyces boulardii, 250 mg twice daily Hydration target: 80 ounces minimum daily Track your primary GI symptoms daily on a 1 to 10 scale

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(2024) and Johnson et al

Int J Mol Sci 23(23):15297