[3] [4] These medications work by mimicking the incretin hormone glucagon-like peptide-1, which enhances insulin secretion, suppresses glucagon release, and significantly reduces appetite primarily through central satiety pathways, with some slowing of gastric emptying (an effect that may attenuate over time)
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The long-term safety profile has not been established
The dose-response relationship demonstrates that higher doses produce greater reductions in HbA1c and body weight, with clinical effects sustained over long-term treatment (Davies et al., 2021)
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Phase 3 TRIUMPH-4 (NCT05931367) reported 28.7% body weight loss at 12 mg, 26.4% at 9 mg, vs 2.1% placebo at 68 weeks