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The GHRP component appeared to sensitize somatotrophs to GHRH by mobilizing intracellular calcium stores through the Gq pathway, while GHRH simultaneously elevated cAMP via Gs

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[265] designed a dual-hormone foam nanomotor capable of overcoming gastrointestinal barriers to reach the rectum

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Collectively, these findings support the interactions of GHK and GHK-Cu complexes with mammalian models as research tools for studying redox regulation, peptide-mediated antioxidant signaling, and oxidative stress modulation