It is produced naturally by the body and is found in every cell, where it acts as a powerful antioxidant and detoxifier
In fact, the Cu 2+ -histidine interaction (binding) in nature can match the importance of iron (Fe 2+ ) binding with proteins, and the consequent haem interactions that support the very existence of life ( Intriguingly, the interactions of N-terminal histidine residues of the prion protein (PrP) mainly with Cu 2+ sequestration and accumulation in diseased brain (T 2+ at neutral pH (7.4) ( 2+ is not necessarily pathogenic since it has also been found to produce neuroprotection due to the cis interaction with the C terminal of PrP
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Nat Commun 2019, 10 (1), 3848
RSOH + H 2 O 2 RSO 2 H + H 2 O Sulfinylation is further oxidation, also common in redox signalling
As folate deficiency leads to several pathological states, current opinions toward prevention through fortification are discussed
