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Disrupting the clock in male mice via adipocyte-specific genetic deletion or high-fat-diet feeding reduces complex I respiration in adipocytes, leading to suppression of the peroxisome proliferator-activated receptor and insulin signalling pathways

Moreover, it was demonstrated that TF-1 interacts with PPFP to inhibit the pro-adipogenic response to pioglitazone and that the ability of pioglitazone to decrease TTF-1 expression contributes to its pro-adipogenic action (Xu et al., 2016)

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