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[7] [9] Additionally, GLP-1 medications have effects throughout the gastrointestinal tract, as GLP-1 receptors are widely distributed in the gut

Upon nutrient ingestion GLP-1 is secreted into the blood from intestinal enteroendocrine L-cells that are found predominantly in the distal ileum and proximal colon with some production from these cell types in the duodenum and jejunum

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The trial found a reduction in HFH, urgent HF visits, or cardiovascular death with dapagliflozin compared to placebo (16.4% versus 19.5%

Early quit-smoking trials are encouraging, too