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Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage (Sies, 2015) that harm lipids, proteins and DNA (Schieber and Chandel, 2014)

However, they can and do cause indirect changes to your thyroid levels (TSH, Free T4, and Free T3), primarily through weight loss and changes in how your body absorbs medication

doi: 10.1016/j.jpsychires.2021.05.036 147 KopfDWestphalSLuleyCWRitterSGillesMWeber-HamannBet al

AzziniEPea-CoronaSIHernndez-ParraHChandranDSaleenaLAKSawikrYet al

Journal of the National Cancer Institute 88, 279284, 10.1093/Jnci/88.5.279 (1996)

Nausea, vomiting, diarrhea, and constipation are the most frequently reported and are usually most pronounced during dose escalation