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Nanodrug regulates lactic acid metabolism to reprogram the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

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To further determine the biological functions of this system, multi-dimensional experimental validation was conducted using cells, in vitro experiments, and in vivo evaluations on mice

Based on our previous microarray analysis (Michael et al, 2023), we next focused on another miRNA, miR-4488, whose levels, similar to miR-4734, changed upon 48 h of starvation

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doi: 10.1186/s12866-025-03904-w 83 LatifA.ShehzadA.NiaziS.ZahidA.AshrafW.IqbalM