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Metabolomic studies have demonstrated dysregulated NAD + metabolism in hepatocytes and plasma across MASLD and ALD (Aggarwal et al

doi:10.2215/cjn.00490206

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Thus far, the major barriers to GLP-1 receptor agonist adoption have been cost and availability

Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible