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438,439 Therefore, based on improved treatment outcome and mitigated adverse effects, the combinatorial therapy dabrafenib plus trametinib has been approved by FDA for treating patients with unresectable or metastatic melanoma harboring BRAF V600E or BRAF V600K mutations

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Expression of Mcl-1 is upregulated in many cancers, and it was seen to be upregulated as a resistance factor to chemotherapies, Keating says