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Other studies have also demonstrated that HIF-1 exerts a suppressive effect on IL-12 production in dendritic cells, thereby restricting the development of Th1 cells and subsequently influencing the balance of immune responses (82).Collectively, these findings suggest that the hypoxic microenvironment, by modulating the expression of HIF-1, may regulate dendritic cell migration capability, glucose metabolism, immune defense capabilities, and T cell activation, thereby exerting profound effects on disease progression