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PMCID: PMC9823656

It usually arises from the opening where the stomach and esophagus meet

Hepatic fibrosis is characterised by the accumulation of the extracellular matrix (ECM)a network of macromolecular proteins that under normal physiological conditions maintains tissue homeostasis, but in excess leads to fibrosis [38]

Clinical Category Guidance & Safety Mandates Thyroid History Warning Strictly contraindicated if you or any family members have a history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

People who participate in physical activities may require alteration regarding the duration of their exercise or moments when they are physically exerting themselves

These contraindications are based on established clinical and pharmacological concerns