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Standard clinical escalation protocol The Phase 2 trial published in the New England Journal of Medicine established the titration schedule that most researchers follow

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That work has previously attracted endorsement from Professor Windy Dryden , a leading figure in CBT, and Professor Philip Zimbardo , the Stanford psychologist known for his work on time perspective

We recommend using a 3ml or 5ml syringe for the water and a smaller 1ml insulin syringe (marked in units or mL) for precise dosing measurements later