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Side effects can be mitigated by using lower doses and combining TZD therapy with other medications (SGLT2i and GLP-1 RA) that promote weight loss and sodium excretion [199, 206]

Glutathione is synthesized in the cytosol of each cell by the action of two enzymes in an elegantly regulated system that allows it to be maintained at different homeostatic levels in different tissue types, with the liver, given its detoxification role, having the highest amounts

Actionable Next Steps for Researchers: Prioritize Monotherapy Research: Continue to focus on understanding the individual properties and safety profiles of MOTS-c and Retatrutide through well-designed preclinical and clinical studies

The company said its own research found that patients could sustain weight loss after stopping obesity drugs