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Disrupted insulin signaling in these brain regions has been linked to changes in eating behavior and may contribute to weight gain and metabolic decline, further worsening insulin resistance

In a previous study, AC demonstrated antihypertensive effects by reducing both SBP and DBP in spontaneously hypertensive rats (Chao-Hsiang et al

2015;10(9):e0138318

Immunofluorescence staining Sections were stained for keratin 19 (K19) (Developmental Studies Hybridoma Bank, TROMAIII), Zonula occludens-1 (ZO-1) (Abcam, ab96587), Vimentin (Abcam, ab92547), and 4,6-diamidino-2-phenylindole (DAPI) (D1306, Invitrogen), as previously described 67

Cochr Datab Syst Rev

& Mnzel, T