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This study was approved by the institutional ethics committee of the First Affiliated Hospital of Anhui Medical University, and written informed consent was obtained from all participants in accordance with the Declaration of Helsinki

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In three different species (i.e., mice, rats, and musk shrews), we show that glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling blocks emesis and attenuates illness behaviors elicited by GLP-1R activation, while maintaining reduced food intake, body weight loss, and improved glucose tolerance