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Missing doses or breaking rules makes oral medication even less effective

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Results indicate predispositions in peptide-pathway activationnot exact medication response or side-effect prediction

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Menstrual cycles may also be altered by low levels of other vitamins, such as vitamin E, as well as by insufficient calcium or magnesium

Nat Struct Biol 6:359365 Holmes MV, Newcombe P, Hubacek JA, Sofat R, Ricketts SL, Cooper J et al (2001) Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials