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Some gerontologists have even proposed melatonin as an anti-aging hormone supplement, given the convergence of its effects on multiple aging hallmarks (oxidative damage, chronic inflammation, impaired sleep/circadian regulation) (Favero et al., 2017

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This phenomenon differs from direct antioxidant activity and represents a form of cellular preconditioning that can enhance resilience against future oxidative challenges

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doi: 10.2903/j.efsa.2010.1678