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But its therapeutic benefits differ

medRxiv (Cold Spring Harbor Laboratory)

Drug Delivery Rev

Ha et al., 2012)

DSIP also exhibits a pronounced stress-protective action and decreases stress-induced metabolic and functional disorders

Moreover, hyperglycemia impairs the expression of Sox9, a key factor of Paneth cell differentiation involved in stem cell maintenance and the expression of stem cell markers Lgr5 and Musashi RNA-binding protein 1 (Msi1) and transit-amplifying cells marker prominin 1 (Prom1)