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The FDA recommends only purchasing from a state-licensed pharmacy to protect yourself

So nothing will change

If staying at very low doses long-term worked as well, RCTs would reflect that by now

Studies on production, characterization and applications of microbial alkaline proteases

In severe cases, sensation may be permanently lost in the hand and the muscles at the base of the thumb atrophy (shrink or waste away), leading to progressive weakness with pinch and grip