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It also indicates a philosophical shift: British policymakers signaled that in a publicly-funded system, extra spending (via tax) on new drugs is justified to unlock more therapies

However, the field is marked by heterogeneous and sometimes contradictory evidence

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( 2+ and ROS, and mitigating peroxidative damage ( While current studies have delineated the core roles of ferroptosis (via the System Xc GSHGPX4 axis, iron overload, lipid peroxidation, and mitochondrial dysfunction) and identified antioxidant networks (Nrf2/Sirtuins/FTH1) as therapeutic targets in DN, several critical research gaps persist that hinder a comprehensive understanding of ferroptosis-driven DN progression and translational application

Diabetes Metab 34(Suppl 2):S65-72 Hygum K, Harslf T, Langdahl B, Starup-Linde J (2019) Glucagon-like peptide-1 receptor agonists and fracture risklimitations to current knowledge