Blood sugar control appears slightly better with tirzepatide in head-to-head trials, possibly due to GIPs robust insulin secretion effects
According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), consuming moderate amounts of healthy fats with meals stimulates gallbladder contraction and bile flow, potentially preventing bile stasis
Abbreviations AAV: Adeno-associated virus AKI: Acute kidney injury ANCA: Anti-neutrophil cytoplasmic antibody ARDS: Acute respiratory distress syndrome AVV: ANCA-associated vasculitis CG: Cathepsin G CTCs: Circulating tumor cells DEK: DNA-binding protein DEK DHTI: 15, 16-Dihydrotanshinone I ECs: Endothelial cells PDG: 2-Fluoro-2-deoxy-D-glucose GM-CSF: Granulocytemacrophage colony-stimulating factor IFN-: Interferon alpha IRA: Infract-related artery JIA: Juvenile idiopathic arthritis MI: Myocardial infarction MMP-9: Matrix metalloproteinase-9 MPO: Myeloperoxidase NE: Neutrophil elastase NEFAs: Non-esterified fatty acids NETs: Neutrophil extracellular traps NOX2: NADPH oxidase 2 OSM: Oncostatin M PAD4: Peptidyl arginine deiminase 4 PAF: Platelet-activating factor Panx1: Pannexin 1 pDCs: Plasmacytoid dendritic cells PMA: Phorbol 12-myristate 13-acetate PMNs: Polymorphonuclear neutrophils PR3: Proteinase 3 RA: Rheumatoid arthritis RCC: Renal cell carcinoma rhDNase: Recombinant human deoxyribonuclease RIPK1: Receptor-interacting protein kinase 1 ROS: Reactive oxygen species Sal B: Salvianolic acid B SLE: Systemic lupus erythematosus STEMI: ST-elevation myocardial infarction SVV: Small vessel vasculitis TAN: Tumor-associated neutrophils TINs: Tumor-infiltrating neutrophils TME: Tumor microenvironment References Hidalgo A, Libby P, Soehnlein O, Aramburu IV, Papayannopoulos V, Silvestre-Roig C
The first twincretin was a unimolecular dual GLP-1R/GIP receptor (GIPR) agonist
But they will be, if history is any indication
A collaborative approach with your GP or diabetes specialist nurse ensures that any adjustments to your treatment plan are made safely and appropriately
