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The exocrine portion accounts for approximately 90% of the pancreas and includes the acini, central acinus, and ductal structures

The FDA label reports nausea in 25%, 29%, and 28% of patients taking Zepbound 5 mg, 10 mg, and 15 mg, respectively, compared with 8% on placebo

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While animal studies cannot definitively rule out human cancer concerns, the consistent absence of tumors or pre-cancerous changes across multiple species, dosing regimens, and administration routes carries meaningful weight

J Biol Chem 293(43):1672416740

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