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This broader mechanism may produce greater metabolic effects, though no head-to-head trials have yet confirmed superiority

If you have limited subcutaneous fat in your arms due to low body weight or significant weight loss, discuss alternative injection sites with your healthcare provider, as the abdomen or thigh may be more appropriate

This may help bust weight and fat loss plateaus in people with good movement habits

However, short term insulin treatment for a maximum of 14 days prior to the day of screening is allowed, as is prior insulin treatment for gestational diabetes

At the same time, some people with type 2 diabetes struggle less with weight management and have insulin resistance that is moderate enough that it can be managed by diet and lifestyle changes alone

These agents have been investigated in peer-reviewed studies for their potential roles in glucose homeostasis and body weight management