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Functional assays confirmed P3s critical role: the P3A mutant failed to promote HUVEC proliferation in CCK-8 assays

These effects include -cell proliferation, increased insulin secretion, weight loss, and glucose-dependent insulinotropic and glucagonostatic functions [8, 9]

Additionally, like GPLC, it also stimulates nitric oxide production.(8,9)

Patients should not attempt to accelerate dose increases independently, as this significantly raises the risk of adverse effects including nausea, vomiting, and gastrointestinal discomfort

A review of the clinical pharmacology of methamphetamine