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[5] After completion of this reaction, glutathione reductase recycles oxidized glutathione back to the reduced form so that it again can be picked up by GSTs

[PUBMED Abstract] Pellegrini C, Maturo MG, Martorelli C, et al.: Characterization of melanoma susceptibility genes in high-risk patients from Central Italy

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It is one of the first peptides discovered to originate from mitochondrial DNA, acting as a retrograde signal that coordinates nuclear gene expression with mitochondrial metabolic demands positioning it at the forefront of longevity and metabolic research