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For these reasons, we believe that ASM participants in small practices would likely score lower than their counterparts in larger practices under ASM, with solo practitioners potentially scoring lower than other small practices
Likewise, another dualAG named cotadutide (MEDI0382) was more effective than obeticholic acid in improving liver metabolism and ameliorating MASH and fibrosis in C57BL/6J or ob/ob mice on a high trans-fat/fructose/cholesterol diet 14 , as well as decreased liver inflammation and apoptosis in adipocytes 15
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Treatment of phLF and phBEC with TGF-1, TNF-, and menadione For treatment of phLF, cells were seeded at a density of approximately 20,000 cells/cm 2 , starved for 24 hours in DMEM/F12 with 0.5% FBS and 100 nM sodium selenite, followed by treatment with 2 ng/ml TGF-1 (R&D Systems, Minneapolis, MM, USA), 10 ng/ml TNF- (PeproTech, Rocky Hill, NJ, USA), and 10 M menadione (Sigma-Aldrich) in starvation medium for the indicated time points
Thus, in a patient treated with GLP-1, weight loss associated with a decrease in SMM/W may reflect a disproportionate muscle loss and point towards a progression to sarcopenic obesity
