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In intracellular GSH synthesis, GCL can be the rate-limiting enzyme under the condition that all substrates are sufficiently present for the reactions, but the intracellular Cys concentration is much lower than those of Glu or Gly under physiological conditions, suggesting that the Cys availability is limiting for GSH synthesis [30,31]

It targets and inhibits the activity of an enzyme known as NNMT, which has been linked to a slowdown in metabolism and a reduction in energy production

10.1016/j.ebiom.2020.102736 EBioMedicine 128 RamtekeA.TingH.AgarwalC.MateenS.SomasagaraR.HussainA.et al (2015)

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