Tang X, Wu H, Mao X, Li X, Wang Y (2020) The GLP-1 receptor herbal agonist morroniside attenuates neuropathic pain via spinal microglial expression of IL-10 and -endorphin
GLP-1 receptor agonists are licensed in the UK for type 2 diabetes and weight management, including semaglutide, dulaglutide, and liraglutide These medications reduce HbA1c by approximately 1.01.5 percentage points and improve both fasting and post-meal glucose levels Weight loss associated with GLP-1 therapy can lead to secondary improvements in insulin resistance, particularly through reduction of visceral fat Common side effects include gastrointestinal symptoms such as nausea, vomiting, and diarrhoea, which typically diminish over several weeks NICE recommends continuation only if patients achieve at least 1.0 percentage point HbA1c reduction within six months of treatment initiation Patients with diabetic retinopathy require close monitoring, and GLP-1 medications should be discontinued at least two months before planned pregnancy Table of Contents What Are GLP-1 Receptor Agonists and How Do They Work
What's inside Ingredients List Water Skin Conditioning Niacinamide Smoothing Helianthus Annuus Seed Oil Emollient Glutathione Cetearyl Olivate Polyacrylamide Sorbitan Olivate Emulsifying 1,2-Hexanediol Skin Conditioning C13-14 Isoparaffin Emollient Pulsatilla Koreana Extract Skin Conditioning Usnea Barbata Extract Zanthoxylum Piperitum Fruit Extract Skin Conditioning Carbomer Emulsion Stabilising Sodium Hyaluronate Humectant Triethanolamine Buffering Parfum Masking Glycerin Humectant Laureth-7 Emulsifying Butylene Glycol Humectant Limonene Perfuming Hexyl Cinnamal Perfuming Linalool Perfuming Ethylhexylglycerin Skin Conditioning Achillea Millefolium Extract Cleansing Malva Sylvestris Extract Astringent Melissa Officinalis Leaf Extract Skin Conditioning Mentha Piperita Leaf Extract Skin Conditioning Primula Veris Extract Skin Conditioning Veronica Officinalis Extract Skin Conditioning Hydrogenated Lecithin Emulsifying Geraniol Perfuming Hamamelis Virginiana Leaf Extract Skin Conditioning Morus Alba Bark Extract Skin Conditioning Phyllanthus Emblica Fruit Extract Humectant Trichosanthes Kirilowii Root Extract Skin Protecting Polyglyceryl-10 Stearate Skin Conditioning Benzyl Benzoate Antimicrobial Panthenol Skin Conditioning Sodium Ascorbyl Phosphate Antioxidant Tocopheryl Acetate Antioxidant Glyceryl Arachidonate Emollient Glyceryl Linolenate Emollient Acetyl Hexapeptide-8 Humectant Biotin Antiseborrhoeic Folic Acid Skin Conditioning Pyridoxine Skin Conditioning Retinyl Palmitate Skin Conditioning Thiamine Hcl Masking Copper Tripeptide-1 Skin Conditioning Oligopeptide-29 Antioxidant Cyanocobalamin Skin Conditioning Oligopeptide-32 Antiseborrhoeic Palmitoyl Pentapeptide-4 Skin Conditioning Water, Niacinamide, Helianthus Annuus Seed Oil, Glutathione, Cetearyl Olivate, Polyacrylamide, Sorbitan Olivate, 1,2-Hexanediol, C13-14 Isoparaffin, Pulsatilla Koreana Extract, Usnea Barbata Extract, Zanthoxylum Piperitum Fruit Extract, Carbomer, Sodium Hyaluronate, Triethanolamine, Parfum, Glycerin, Laureth-7, Butylene Glycol, Limonene, Hexyl Cinnamal, Linalool, Ethylhexylglycerin, Achillea Millefolium Extract, Malva Sylvestris Extract, Melissa Officinalis Leaf Extract, Mentha Piperita Leaf Extract, Primula Veris Extract, Veronica Officinalis Extract, Hydrogenated Lecithin, Geraniol, Hamamelis Virginiana Leaf Extract, Morus Alba Bark Extract, Phyllanthus Emblica Fruit Extract, Trichosanthes Kirilowii Root Extract, Polyglyceryl-10 Stearate, Benzyl Benzoate, Panthenol, Sodium Ascorbyl Phosphate, Tocopheryl Acetate, Glyceryl Arachidonate, Glyceryl Linolenate, Acetyl Hexapeptide-8, Biotin, Folic Acid, Pyridoxine, Retinyl Palmitate, Thiamine Hcl, Copper Tripeptide-1, Oligopeptide-29, Cyanocobalamin, Oligopeptide-32, Palmitoyl Pentapeptide-4 Key Ingredients Benefits Concerns Ingredients Explained Water
So the honest takeaway is this: the association is plausible and supported by early observational signals, but causation and true risk magnitude still need better studies
I want to say, [clears throat] fundamentally, what GLP-1s had to do, because the body positivity movement had been so successful at dismantling diet culture, is they had to fundamentally say, "We're not diet culture." This is where all this co-optation of weight stigma language
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