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As of June 2025, retatrutide has not received marketing authorisation from the MHRA or EMA and cannot be legally prescribed or dispensed in the UK outside of an authorised clinical trial

While much research focuses on bariatric surgery patients, the mechanisms of B12 deficiency during rapid weight loss overlap significantly with GLP-1 therapy

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In PsA patients, WAT localized in entheses-associated regions like the retrocalcaneal fat pad, shows impaired lipolysis, reduced adiponectin secretion, and increased fatty acid -oxidation, possibly emphasizing its pathological significance [48,49,50]