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Limitations and Considerations The number of non-white participants was low, which may limit the generalizability of results

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However, the oncological significance of GCG signaling remains insufficiently defined, and the currently available evidence does not support a uniform conclusion that GCGR activation exerts a direct antitumor effect (61)

Even small amounts of degradation products or synthesis impurities can introduce unintended receptor interactions or background signaling activity that complicates interpretation in receptor binding assays, metabolic pathway studies, and cell-based experiments

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