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Chu et al showed that systemic levels of IGF-I can be restored by intravenous delivery of an AAV vector encoding mouse IGF-I(Eb) cDNA, in a streptozotocin (STZ)-induced mouse model of diabetic peripheral neuropathy

Funding HCJ discloses support for the research of this work from the Prime Ministers Research Fellowship, Ministry of Education, Government of India [PMRF ID: 2100556], the Department of Science and Technology, Government of India, under the Fund for Improvement of S&T Infrastructure scheme [SR/FST/LS-I/2020/621], and Anusandhan National Research Foundation (ANRF) for funding through the PAIR scheme (File No: ANRF/PAIR/2025/000018/PAIR-A(G))

Blood glucose monitoring becomes especially important to catch any unexpected drops or patterns that emerge from the combination

A 2006 Phase I trial of CJC-1295 reported no serious adverse events across a small number of subjects, but it was a safety study, not an outcomes trial, and there are no large trials showing it does what enthusiasts hope

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Downregulates monocyte chemoattractant protein-1 (MCP-1) expression in nephropathy mice models, curtailing monocyte trafficking and M1 prevalence [176]