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We focused our BM cytokine analysis on those related to T cell activation, proliferation, differentiation, and metabolism 13 , including IL 1, 2, 4, 5, 6, 7, 8, 10, 12, 13, 15, 17, IFN and TNF, and found no significant differences between the two cohorts (Fig

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The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)

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[DOI] [PubMed] [Google Scholar] 42.Cohen S., Kamarck T., Mermelstein R