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Lancet 1998

In vitro investigations have demonstrated that selenomethyl selenocysteine is capable of diminishing ROS levels, stabilizing the levels of prolyl hydroxylase-2 (PHD2) and prolyl hydroxylase-3 (PHD3), and downregulating HIF-1 expression in colon and head and neck cancer cells

The FDA's Pharmacy Compounding Advisory Committee has meetings scheduled for July 2026 to formally review them for Category 1 placement