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The leading explanation is amplification of a pain-signaling channel on skin sensory nerves (purinergic ATP/P2X signaling). Symptoms were usually mild and eased after dose reduction

A notable finding from CagriSema trials: the GI side effect profile of the combination was similar to semaglutide monotherapy , not meaningfully worse

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It promotes healing by upregulating growth factors, stimulating angiogenesis (new blood vessel formation), and enhancing collagen synthesis

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Potentially Permanent Relief: For many patients, especially those with severe, debilitating pain unresponsive to other treatments, surgery can provide long-term or permanent relief from chronic back pain, dramatically improving mobility, function, and overall quality of life