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DDIs occur when one drug alters the pharmacokinetics or pharmacodynamics of another, leading to: Increased toxicity Reduced efficacy Unexpected clinical outcomes Most clinically relevant DDIs are mechanism-driven, not accidental

Common side effects may include nausea, vomiting, diarrhea, constipation, reflux, decreased appetite, or abdominal discomfort

Each has a different pharmacology, side-effect profile, and regulatory status

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