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Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, NRF2) is a transcription factor that governs the antioxidant pathway, targeting GSH metabolism-related genes, including GCLC, GCLM, and SLC7A11 41,49

Its role in detoxifying harmful metabolites, such as hydrogen peroxide (HO), further enhances its protective effects on cardiomyocytes and endothelial cells

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FAE mediate their anti-psoriatic effects via activation of several cellular pathways that induce T-cell apoptosis or prevent release of proinflammatory cytokines (Figure 1)