At low doses, it temporarily blocks opioid receptors for a few hours, typically overnight, causing the brain to compensate by producing a surge of its own endogenous endorphins and enkephalins
Feldman HA, Erasmus JJ, Zhou N, Antonoff MB, Mehran RJ, Rajaram R, Rice DX, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Hofstetter WL , Betancourt SL
Cell Death Differ 24:14751477
Hemoglobin A1c reductions become apparent after 12 to 16 weeks of consistent treatment
16 The injectables flood the body with very high levels of synthetic versions of GLP-1 for extended periods of time, so it makes sense that the body doesn't see any 'need' to make its own
Plants 8(11):508 Kumar Tewari A, Charan Tripathy B (1998) Temperature-stress-induced impairment of chlorophyll biosynthetic reactions in cucumber and wheat