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Ultimately, GLP-1s arent for everybody
One study (from 1999) mentions the issue described above, but it is not a credible source for the following reasons: The study wasn't performed on normal human proteins or healthy, intact skin (instead, a blend of animal and human proteins, and the pH relationship issue developed only when a fatty acid byproduct was added to the mix)
For the most part, the trials are good-quality pieces of research, with double-blinding to ensure neither patients nor their doctors knew whether they were getting semaglutide or placebo in their injections
A 2023 Nature report at the beginning of the year, extolling breakthrough obesity drugs, focused just on Habener and Drucker
