However, the differences between agents remain unexplored
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In preclinical studies, inhibition of AGE formation, or interventions that break their cross-linked structure, have been shown to delay the development of nephropathy, even without directly impacting blood sugar control (Forbes 2003)
Sulfonylureas, first under investigation in the 1940s as antibacterial agents, and TZDs, investigated in the 1980s as a lipid lowering therapies, were observed to induce hypoglycemia in animal models, and were then repurposed as antidiabetic drugs (95,96)
By contrast, lesioning or stimulating the LH decreases or induces appetite, respectively
