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Gynecomastia affects males across a wide range of age groups, with some statistics reporting that between 35% and 45% of males at some point in their life will suffer from gynecomastia

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Low-grade inflammation (median hsCRP approximately 4.1 g/mL) and immune activation markers were common, underscoring the clinical relevance of slowing biological aging in this setting

Different pathways have been recently identified to play a key role in the escape of the immune system in senescence, highlighting the potential development of significant senolytic therapies in the future (Fig