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The caveat: facial fat distribution continues changing as weight decreases, which means a treatment that looks right at your current weight may look different at your goal weight

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Obesity also covers a wide range of systemic issues like insulin resistance due to increased weight gain and expression of inflammatory cytokines

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I kind of preface by saying we dont know who will respond and how they will respond, how much weight a certain individual may lose, and how that may also impact their health overall, says Jastreboff, who is director of Yale Universitys Obesity Research Center