Semaglutide's primary mechanismslowing stomach emptying via GLP-1 receptor activationdirectly increases the time bacteria in your colon have to ferment undigested food, producing gas as a byproduct
Paul SK, Klein K, Thorsted BL, Wolden ML, Khunti K
however, all side effects were mild
Considering Danish costs of medications, diabetes consumables, and treatment of diabetes-associated complications, modelling all four trials over a 40-year horizon, these analyses indicated that treatment with either oral or subcutaneous semaglutide (a GPL-1RA) was likely to increase both costs and health benefits relative to empagliflozin, canagliflozin (SGLT-2is), and sitagliptin (DDP-4i) for treatment of patients with type 2 diabetes that is not adequately controlled with metformin (with or without sulfonylurea) in Denmark
"Agreed, there are fewer women at age 50 who are considered high risk, but those women should not be ignored," Gulati said
Cognitive impairment phenotypes in patients with CKD stages 3b and 4