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Growth hormone exerts both direct and indirect effects on bone metabolism through actions on osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells), while IGF-1 serves as a primary mediator of growth hormone's anabolic effects on skeletal tissue
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Ballesteros A, Summerfelt A, Du X, Jiang P, Chiappelli J, Tagamets M, ODonnell P, Kochunov P, Hong LE
CHETAH: a selective, hierarchical cell type identification method for single-cell RNA sequencing