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doi: 10.1016/j.seizure.2006.05.007

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A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

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This "step therapy" approach, common in pharmaceutical benefit management, could make orforglipron the default first-line GLP-1 therapy for many patients, with injectable options reserved for orforglipron non-responders or patients with specific clinical needs for higher efficacy