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The sugar hydroxyls are acetate-protected to increase lipophilicity for cell membrane permeability
3 / Synthetic glycopeptide
or pentafluorophenyl (PFP) esters and reacted with amine-functionalized payloads
52 / / Nilotinib N-Oxide / 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) phenyl]-3-[[4-(3-pyridinyl-N-oxide)-2-pyrimidinyl]amino]benzamide
27 / A β-D-galactose ligand equipped with a thiol-functionalized linker through a short ethyl spacer
MV100052: Tris-GalNAc-PEG5-NHS Ester label-new The sugar hydroxyls are acetate-protectedC79H137N11O37 1832. 98 A triantennary N acetylgalactosamine (Tri GalNAc) ligand presenting three GalNAc residues on a tris based branched scaffold, equipped with an N hydroxysuccinimide (NHS) activated ester through a discrete, monodisperse pentaethylene glycol (PEG5) spacer. The NHS ester reacts with primary amines to form stable amide bonds, providing a single step route to conjugate the Tri GalNAc ligand onto amine bearing payloads, antibodies,
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