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Goodband, J.L

Preclinical studies have also demonstrated the direct involvement of IDO in the development of depressive-like behavior that was induced by an inflammatory insult

Although the exact clinical significance in humans remains unclear, preclinical research has focused on three main areas

Even in this stage, people may experience symptoms such as anxiety , fatigue , miscarriage/infertility, mood swings, excess weight , or weight loss, because their body is fighting hard to keep their thyroid levels normal, and this can be exhausting and draining on the usual body functions and nutrients

For example, gradual dose escalation helps the body adjust over time, minimizing the frequency and severity of GI symptoms

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